They are also useful for patients with vomiting from toxic agents, from chemotherapy and after surgery. These drugs tend to induce relaxation and somnolence and are generally used parenterally or as suppositories in patients with acute intense vomiting of central origin, as in vertigo, migraine headaches, and motion sickness. The phenothiazines (chlorpromazine, perphenazine, prochlorperazine, promethazine, and thiethylperazine) and butyrophenones (droperidol and haloperidol) also block D2 dopaminergic receptors in addition to muscarinic M1 receptors phenothiazines also block histamine H 1 receptors.
Mark Feldman MD, in Sleisenger and Fordtran's Gastrointestinal and Liver Disease, 2021 Phenothiazines and Butyrophenones
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